Thursday, September 15, 2011

Windows 8 developer preview: when and where to download (update: right now, here!)

Got a brain full of Windows 8? Can't stop obsessing about it? Fret not -- as of 8PM PT this evening (just under eight hours from now), you'll be able to download a copy of the Windows Developer Preview to your 32- or 64-bit x86 machine (no activation required) from dev.windows.com. Sorry, ARM hopefuls! Per usual, we'd recommend doing so on a separate partition (or a spare machine altogether) in order to prevent unforeseen conflicts, and we'd also suggest having a stiff glass of patience waiting nearby. Something tells us Redmond's servers are going to be hammered.

Update: The download is live! Click here to try it out yourself, while the slightly less daring can hang on for our first impressions of Microsoft's latest and greatest once we've installed and given it a try.

[Thanks to everyone who sent this in]

Windows 8 developer preview: when and where to download (update: right now, here!) originally appeared on Engadget on Tue, 13 Sep 2011 20:23:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/09/13/windows-8-developer-preview-when-and-where-to-download/

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Wednesday, September 7, 2011

4 Things to Do After a Home Swap

Home swaps can be really fun and interesting particularly when you find the home of your choice and are able to tidy things up with the other party. Most people tend to wonder, what next after they have moved into a new place from another apart from the usual settling in. Anyways, there are many things that you can do immediately after a home swap and after you have settled in. These include:

1. Get in Touch With the landlord of your property

The very first thing you ought to do when you get to the new place after doing a bit of unpacking and settling in of course is to contact the landlord of the place and inform them of your arrival. Usually, they will offer to help you with anything to settle in. If you have any questions about anything, this is the right time to ask.

2. Call or Get in Touch with your mutual exchange partner

The next thing you should do is get in touch with your mutual exchange partner and see if they have settled well into your previous home and if they need any help. Simple as this may seem, doing this not only shows that you are thoughtful and kind, it also shows that you know what you're doing and are considerate of others' needs.

3. Clear the Listing

If you listed the property on a mutual exchange website or service, it is important for you to remove it and probably indicate that the swap has already been made. This will help the websites and mutual exchange services make room for other listings while not leaving room for any misdirection.

4. Settle in

The next obvious thing to do would be to settle in and see what the place looks like. Most people usually carry out their research about the new place before moving to there. However, if you know what you are doing, you may have to interact with the locals after you have unpacked and settled in. This is because most times, what you may read online or in newspapers may not be as stated. There may be a hot new pub down the road that wasn't mentioned or a decent lounge where you can relax in the evenings.

As you can see, these things aren't so difficult to do. All it takes is a bit of time and you're good.

If you are looking for a homeswap, home-swap.co.uk is a home swap website allowing tenants to find an mutual exchange. For more council house exchange adverts, you could also try councilhouseexchange.co.uk where tenants can also list a mutual exchange.

Source: http://compare-removals-quotes.co.uk/content/moving-articles/2984-4-things-to-do-after-a-home-swap

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Sunday, September 4, 2011

Ask Martha: Birds as pets, car crafts for kids | crafts

Q: I live in an unit and would like to have birds as pets, though we don?t wish them to disquiet my neighbors. What breeds do we suggest?

A: Birds make poetic companions, though selecting a right one for your resources is pivotal for a rewarding relationship. Steer transparent of parrots since their gibberish will be heard in circuitously apartments. Even tiny parrots such as budgies have outsize voices that lift by walls, floors and ceilings.

Better choices embody zebra finches, multitude finches and colorful Gouldian finches, according to Marc Morrone, a horde of Martha

Article source: http://www2.timesdispatch.com/lifestyles/2011/sep/04/tdflair07-ask-martha-birds-as-pets-car-crafts-for--ar-1277537/

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Source: http://joelfinnigan.com/crafts/ask-martha-birds-as-pets-car-crafts-for-kids/

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Congress returns, unpopular as well as divided (AP)

WASHINGTON ? Congress returns to work this coming week, divided over measures to create jobs and scorned by the nation it was elected to help lead.

After a five-week break, Republican and Democratic leaders alike promise action to try and ease the country's 9.1 percent unemployment rate and boost an economy that is barely growing. President Barack Obama goes first on Thursday night with a speech to lawmakers and a prime-time national television audience.

But there is little overlap so far in the measures that Republicans and Democrats are recommending, and the rest of the year-end congressional agenda is top-heavy with items that relate to government spending and less directly to job creation.

A new committee, comprised of lawmakers in both parties from both houses and armed with extraordinary powers, is expected to hold its first meeting this week as it begins work on a plan to make long-term deficit cuts. The panel was created as part of last month's agreement to reduce red ink and avert a government default. It faces a Nov. 23 deadline for action.

More immediately, parts of the Federal Aviation Administration will shut down on Sept. 16 unless Congress approves a measure to keep operations running. Federal money for highway construction jobs runs out two weeks later without separate legislation.

The Obama administration is seeking more money for disaster relief in the wake of Hurricane Irene, and a partial government shutdown would occur on Oct. 1 unless lawmakers enact an interim spending bill to cover most federal agencies.

With any or all of these measures, there is an opportunity for partisan gridlock or compromise, and it isn't entirely clear which an unhappy public might prefer.

In a late-August Associated Press-GfK poll, only 12 percent of those surveyed said they approved of the job Congress is doing, and 87 percent disapproved. A separate Gallup survey, taken in midmonth, found 13 percent approved and 84 percent disapproved.

"Everybody is kind of in trouble with the electorate," said Republican pollster Bill McInturff. He recently distributed an analysis that concluded the negotiating surrounding last month's agreement to avoid a default is `an extremely significant event that is profoundly and sharply reshaping views of the economy and the federal government.

"It has led to a scary erosion in confidence in both, at a time when this steep drop in confidence can be least afforded."

But if the public was offended by the bickering before the deal, there isn't there much evidence that the compromise on the nation's borrowing limit did much, if anything, to restore confidence in Congress' ability to address economic problems.

A Fox News poll last month showed opinion was split on the compromise, with Republicans overwhelmingly opposed, independents solidly so and Democrats narrowly in favor. But even those statistics masked a deeper divide.

Based on other surveys, McInturff said, "Republicans disapprove because some didn't think we should have raised the debt ceiling at all ... and others because they believe there should have been substantially more spending cuts than what was in the debt ceiling vote."

Independents who disliked the compromise tended to say they wanted deeper deficit reductions. Democrats who disapprove did so because "they can't believe the president is negotiating doing this much with the Republicans," he said, which is a far different reason from the one GOP voters cite.

The Fox News survey showed a similar breakdown.

Republicans and Democrats offer different assessments of the state of congressional approval.

"I'm not the least bit surprised that the rating of Congress is abysmal. If we could do the work that we are supposed to be doing in a reasonable and timely way," it would improve, said Sen. Pat Toomey, R-Pa., a first-termer who is a member of the committee charged with finding $1.2 billion or more in deficit reductions.

Senate Majority Leader Harry Reid, D-Nev., had a somewhat different view, telling an audience in his home state: "Everyone complain all you want about Congress. You should complain plenty. But don't think the country is about to fall apart because of what's going on in Washington."

Already, the differences are evident as Obama and congressional leaders ready job creation plans.

House Majority Leader Eric Cantor, R-Va., recently distributed a list of "Top 10 Job-Destroying Regulations" and said the Republican majority would begin voting this month to block them one by one.

Most, including one that Obama ordered scrapped Friday, deal with pollution limits for a variety of industries; two would curtail National Labor Relations Board actions opposed by business.

Separately, Cantor wrote, the House will "pursue tax relief designed to help American employers create middle-class jobs."

Obama, too, is considering tax breaks to provide businesses to hire new employees. He also is expected to call for new spending on construction projects, and to seek an extension of jobless benefits and a temporary payroll tax cut that is due to expire Dec. 31.

To offset those costs, the president is expected to challenge lawmakers on the debt-reduction committee to go beyond its minimum goal of $1.2 trillion in long-term savings.

The panel marks the latest and possibly the last attempt of the year to forge a sweeping agreement that can cut trillions from future deficits. Congress must approve $1.2 trillion in deficit cuts to block across-the-board spending cuts that both sides say they would like to avoid.

There are expressions of optimism, but so far, none of outright success.

Reid put the prospects of a compromise at 50-50.

Toomey said he was "cautiously optimistic."

"We know how difficult this task is going to be, and I am heartened by the strong encouragement I have gotten from my constituents and my colleagues on both sides of the aisle," Rep. Fred Upton, R-Mich., said Friday in a written statement. "We'll begin by identifying those areas where we have common ground, and we are ready to roll up our sleeves and get to work."

Source: http://us.rd.yahoo.com/dailynews/rss/uscongress/*http%3A//news.yahoo.com/s/ap/20110903/ap_on_go_co/us_unpopular_congress

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Saturday, September 3, 2011

Analysis: Lagarde shows independence from Europe as IMF chief (Reuters)

WASHINGTON (Reuters) ? New IMF chief Christine Lagarde's call to recapitalize European banks by force struck a nerve among the continent's Europe's policymakers and showed she is not afraid to challenge her former peers as many feared she might be.

The message Lagarde delivered from the International Monetary Fund was not new -- it had been shared privately with European policymakers in the past. The difference is that the former French economy minister took the message public.

Speaking before top central bankers, finance officials and a phalanx of journalists at the Federal Reserve's annual retreat in Jackson Hole, Wyoming, on Saturday, Lagarde argued a recapitalization of European banks was urgently needed to erect a firewall against Europe's debt crisis.

A draft of the IMF's Global Financial Stability Report, to be released in late September, has estimated European banks could face a capital shortfall of up to 200 billion euros ($287 billion), according to a European source on Wednesday.

The pushback from Europe's politicians, who argued their bank balance sheets were just fine, took the IMF by surprise, but the reaction showed the officials got the message.

"Either she had been misinformed by her staff at the IMF, that's a possibility, or she did not have French banks in mind," said Christian Noyer, head of the Bank of France, in an interview with French television station BFM.

Emerging market economies have long called on the IMF to show evenhandedness in its advice to member countries, including the advanced economies that have always shunned the fund's advice.

Jacob Kirkegaard, a research fellow at the Peterson Institute for International Economics in Washington, said Lagarde had chosen the right subject to pick a fight with her former European colleagues.

"It illustrates that Lagarde is evidently not treating Europeans with velvet gloves," said Kirkegaard, noting that many of those she offended had supported her nomination to the IMF's top post. "She has chosen a good subject over which to show her independence," he added.

REPEATING THE MESSAGE

While Lagarde is likely to flesh out her thinking on bank recapitalization in the run-up to meetings of financial chiefs in Washington on September 23-25, the IMF has been saying since the global financial crisis erupted that weaker European banks were undercapitalized.

International markets have also yet to be convinced that European banks are sound despite successive stress tests, which Lagarde had backed as finance minister. Eight of 90 lenders failed those tests with a total capital shortfall of 2.5 billion euros.

"Markets fundamentally don't believe that many of Europe's banks hold enough capital," said Kirkegaard. "They thus question the solidity of the entire European banking system."

Questions over the health of balance sheets weighed down by European government debts has made it difficult for some banks to find the capital they need. But officials in Europe argue that reflects a problem of liquidity and not of solvency.

Lagarde's concern is that the world economy has entered, in her words, a "dangerous new phase" and that politicians do not have the conviction to take the tough steps needed to tackle the problem.

The danger is that European growth could slow further, or that the world economy may suffer another recession, which would worsen Europe's debt crisis and put weak banks further at risk.

One way to cut the close ties between sovereigns and the banking sector is to combine credible medium-term fiscal tightening with efforts to strengthen the financial system, including requiring more capital as a bulwark against credit risks and a potential economic slowdown.

While Lagarde believes banks should first try to raise the money themselves, the difficult market conditions that have left some banks without access to wholesale funding may instead require funds from the European Financial Stability Facility.

The EFSF is similar to the U.S. bank bailout program rolled out at the height of the financial crisis in 2008 to bolster the capital of viable financial institutions.

"Alas, there is little reason to believe that EU leaders will follow Lagarde's advice and inject government money into Europe's undercapitalized banks, however," Kirkegaard said, adding: "The time may come before long when they realize that they should have listened to her recommendation."

(Editing by Gary Crosse)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20110901/bs_nm/us_imf_lagarde

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Friday, September 2, 2011

Jennerex Shows that Unorthodox Cancer-Fighting Virus Can be ...

Luke Timmerman 8/31/11

Most patients who take cancer drugs today get them through an intravenous infusion. Scientists have never been quite been able to consistently get this delivery route to work for genetically engineered cancer-fighting viruses, but San Francisco-based Jennerex Biotherapeutics is reporting today that it has found a way, in a move that could help its oncolytic viruses break out of a narrow market niche.

Instead of relying on a direct injection into a single bulky tumor, the usual way oncolytic viruses are delivered, Jennerex and its collaborators were able create an IV formulation that migrated from the bloodstream into tumors, according to research published this week in the journal Nature. The study looked at 23 patients with a variety of tumor types, and found that the drug made its way into tumors in greater amounts when given in an escalating series of doses. Side effects were mostly mild to moderate flu-like symptoms that lasted a few days, consistent with prior studies of the other formulation.

?The idea has been around for decades, but nobody has been able to show you could deliver [an oncolytic virus] through an IV. If you can achieve IV delivery, it opens up the possibility of treating 10-fold more tumors,? says David Kirn, the CEO of Jennerex, and the lead author on the scientific publication.

No one has yet come up with an FDA-approved therapy from this field of oncolytic viruses, although plenty have tried. Jennerex is one of a handful of companies, along with Calgary, AB-based Oncolytics Biotech (NASDAQ: ONCY) and Woburn, MA-based Biovex (recently acquired by Amgen), pursuing the method.

The basic idea here is to genetically modify viruses to selectively infect tumors, replicate like crazy in there, and cause the cancer cells to burst. Most of the treatments, Jennerex?s included, are also designed to provoke an immune reaction to mop up residual cancer cells. Jennerex reported some encouraging, albeit preliminary, results last May from a clinical trial of its experimental oncolytic virus, when it was directly injected into the tumors of 30 patients with liver cancer.

Jennerex CEO David Kirn

But the new intravenous study, which started about 18 months ago, gives Jennerex a potentially more attractive delivery route for liver cancer patients, and opens the door to treating other malignancies, beyond just helping people with inoperable liver tumors.

Here?s how the study worked. Researchers gave just a single IV infusion of Jennerex?s JX-594, and then followed up one week later to take a biopsy from each patient, Kirn says. Scientists looked at those biopsies a couple of different ways, through traditional pathology staining, and through quantitative PCR measurement, to see if the drug infected the tumor, and if so, to what extent. Patients were given an escalating series of five doses. While the drug didn?t appear to have any effect at the lowest dose, it infected tumors in increasing concentrations as the doses got higher, Kirn says.

?We were worried at the start that we were looking for a needle in haystack, that we could miss seeing a replicating virus if it was spotty in the tumor. What surprised us was the extent of replication in tumors,? Kirn says.

This work is still at a very early stage, so all the usual caveats apply. Researchers will need to show the IV method can work with the repeated dosing required in real-world cancer treatment, and that the drug can help people live longer with acceptable side effects. Doctors will want to know which specific forms of cancer are most vulnerable to this treatment method (so far, it looks like liver and colon cancer, Kirn says).

But the early findings are encouraging enough that Jennerex is incorporating the IV dose into the design of an ongoing a 120-patient Phase II liver cancer study, and plans to use it in a Phase III study to come later, Kirn says. Jennerex recently raised $8.5 million to finance the Phase II liver cancer study, which should be enough to run the company through the first quarter of 2013, when it expects to find out whether its drug offers longer survival times than today?s best supportive care, Kirn says.

Luke Timmerman is the National Biotech Editor of Xconomy, and the Editor of Xconomy Seattle. E-mail him at ltimmerman@xconomy.com or follow him on Twitter at twitter.com/ldtimmerman.

Source: http://www.xconomy.com/san-francisco/2011/08/31/jennerex-shows-that-unorthodox-cancer-fighting-virus-can-be-delivered-the-usual-way/

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Thursday, September 1, 2011

Finding A Vehicle Leasing Plan That Works For You ? Every Article ...

When it comes to choosing the right vehicle leasing plan for your needs, there are some important things to take into consideration. Each business and individual requires different needs, which can generally be met using one of the common plans. Within each plan is a variety of specifics to consider and this will require further investigation, but here is a general list of options available.

Leaseback ? Businesses that want to free the capital from a purchase generally choose the leaseback option. This involves leasing back to the company from which it was bought. A separate contract is drawn up usually to the tune of a contract hire variety.

Finance lease: Businesses and individuals looking to lease without the pressure of worrying about the car after the contract generally choose this option. This lease involves a company leasing the vehicle for a fixed amount of time and requires monthly payments from the lessee. Although not across the board, these contracts generally put the cost of taxes, insurance, and services on the company issuing the lease.

Finance lease: A form of commercial leasing, this type of lease involves a fixed time period from a company that owns the car. A client is expected to pay monthly installments on the vehicle as well as the cost of insurance, taxes, and other potential expenses. Depending on the company, these types of contracts differ, and can potentially save customers a large amount of money.

Contract hire: One of the more common forms of lease, the contract hire involves small monthly payments on the part of the lessee on an item that is purchased by a finance company. This company will purchase the vehicle, takes on the risk of depreciation, and decides what to do with the vehicle once the contract expires. These types of options differ depending on the parties involves, but most of these types of contracts fall within the length of 2 to 5 years.

Contract hire: An arrangement which both businesses and personal owners use, it involves small payments each month over a long period of time. A finance company will buy the car and take any risk of depreciation and what happens to the car after the contract has expired. Contracts are generally between 5 years and all customers are subject to a credit check. This option is generally very flexible and be tailored to fit specific needs of both businesses and individuals.

Vehicle leasing is a wise choice as it will help you save money. Getting a car lease is not as hard as you may think it is.

Related posts:

  1. Is Vehicle Leasing More Advantageous Than Purchasing Your Own New Car
  2. Car Leasing And Why It Is Better Than Buying
  3. Guidence On Deciding Between Car Leasing and Van Lease For Families
  4. Vehicle Leases And How To Locate A Deal
  5. Top Five Reasons to Get Contract Hire Leased Vehicles

Source: http://financecalifornias.com/3094/finding-a-vehicle-leasing-plan-that-works-for-you/

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